http://biomechanicalregulation-lab.org/pictures1 daily 0.75 2017-08-27 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893026705-P8BUS5XW8SD7RGWS8SVW/oscar+selfie+2.jpg Pictures From left to right: Front: Muge and Irene. Back: Ben, Antonis, Simon, and Ernesto...sometime after the Oscars ceremony 2014 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893026705-P8BUS5XW8SD7RGWS8SVW/oscar+selfie+2.jpg Pictures From left to right: Front: Muge and Irene. Back: Ben, Antonis, Simon, and Ernesto...sometime after the Oscars ceremony 2014 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893036259-NNWCNICGDLMP944YHA61/second+the+queen%27s+arms+April+2014.jpg Pictures The Queen's Arms. Spring 2014. From left to right: Mario, Muge, Antonis, Simon, Irene, and Ernesto https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893070470-VP5JNBV10O1VXAQ4Y9UG/the+queen%27s+arms+April+2014.jpg Pictures The Queen's Arms. Spring 2014. From left to right: Simon, Muge, Ben, Armando, Antonis, Ernesto, Irene, and Mario https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893050012-S0Y0ZLSJA2M374UUNAH8/Xmas_dinner_Los+Navarros_20_Dec_2013.jpg Pictures Christmas dinner Los Navarros December 2013. From left to right: Linda, Antonis, Diane, Francesco, Ernesto, Armando, Muge, and Ben https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1399893086566-YM9Y64ZREQ5GIJTEDJY9/FRayli+farewell+1+autocontrast.jpg Pictures Frayli's farewell Eastside Bar Summer 2013. From left to right: Armando, Antonis, and Frayli https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1404132070538-9NLPH0XZRO2OD2SGHZFW/P6270258.JPG Pictures Irene's farewell drinks, 2014. From left to right: Antonios, Ernesto, Muge, Mario, Will, Irene, Ben https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1435920934516-KEV0ZD2DHTA9AYHSM0YY/icecreamPhoto.jpg Pictures Ice-cream on a rare sunny day, 2015. Back row, left to right: Asmita, Muge, Hairuo, Simon, Darek, Rebecca. Front row, left to right: Ernesto, Antonios, Will, Ben. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1441801724891-LXOCXUCBAG44YOU2ZUZE/P_20150909_130635.jpg Pictures Ernesto's birthday, 2015. Left to right: Will, Darek Ernesto, Simon, Muge, Hairuo. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1449832351530-ZI9L2DKXJZ4H3RE46O4N/image-asset.jpeg Pictures Christmas dinner 2015. From left to right: Ben, Ernesto, Antonios, Tyler, Daniel, Kalpi, Zaida, Armando, Darek, Andrea, Muge, Will, Alistair, Carol, Marco. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1465563017121-35ZA0RDH2OJ0MG57T93Y/Zaida_bday.jpg Pictures Zaida's birthday, 2016. From left to right: Darek, Alisatir, Antonios, Will, Ernesto, Sophie, Zaida, Muge. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1465563207994-VV6TUAV5KV2IKNHX7JPD/20160609_220832.jpg Pictures Alistair & Tyler pass their ESA and Darek passes his LSR. From left to right: Ernesto, Alistair, Daniel, Darek, Tyler. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1467716206027-OZJAIN4A6PSWJ9X05F67/group.jpg Pictures The team celebrate the latest publication. From left to right: Darek, Marco, Muge, Will, Sophie, Ernesto, Zaida, Ben, Antonios, Daniel, Alistair, Tyler. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1483965307975-3AETPQJC7ZWBDWIBN5U5/Xmas+meal.jpg Pictures https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1473251184090-BL5YW8DMTMHFEW2FIE80/20160831_1853301.jpg Pictures The team, summer 2016. From left to right: Rebecca, Tabitha, Ben, Ernesto, Alistair, Daniel, Antonios, Tyler, Armando, Will and Darek. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496673343625-RWALZHW37ZHK8MSC0EBX/crossing+the+mississippi.jpg Pictures - Crossing the Mississippi River - back home from the Gordon Research Conference in Texas, February 2017 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1503843270494-JH8CQQECXI63LQEE8H45/antonis+viva+1.jpg Pictures Celebration after Antonis' viva (25 August 2017). Darek, Armando, Mark Morgan (external examiner) and Antonis) http://biomechanicalregulation-lab.org/news daily 0.75 2020-01-09 http://biomechanicalregulation-lab.org/news/2019/10/1/chemically-functionalised-graphene-fet-biosensor-for-the-label-free-sensing-of-exosomes-scientific-reports-jrwxl-rk7xa-4hmmw-cl3m7 monthly 0.5 2020-09-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1595601534846-1AUXW5WBQ7HZ6193SQA8/Biogel2.png News - A Knowledge Transfer Partnership (KTP) between the CMBL and Manchester Biogel Ltd http://biomechanicalregulation-lab.org/news/2019/10/1/chemically-functionalised-graphene-fet-biosensor-for-the-label-free-sensing-of-exosomes-scientific-reports-jrwxl-rk7xa-4hmmw monthly 0.5 2020-01-27 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1580162555283-VQ80GV2L9ZU5EINREBT8/model.jpg News - GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoA http://biomechanicalregulation-lab.org/news/2019/10/1/chemically-functionalised-graphene-fet-biosensor-for-the-label-free-sensing-of-exosomes-scientific-reports-jrwxl-rk7xa monthly 0.5 2020-01-09 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1578580377892-8V1QIFQ4JT4KL6AJM5E5/cover_Syndecan_sketch_v2_A4_300ppp.jpg News - Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway - Nature Materials Credits: 3DforScience - Visuals for Bio & Health www.3DforScience.com http://biomechanicalregulation-lab.org/news/2019/10/1/chemically-functionalised-graphene-fet-biosensor-for-the-label-free-sensing-of-exosomes-scientific-reports-jrwxl monthly 0.5 2019-12-09 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1575908967900-SEMG13EHRMNL1T7DEWHN/ELLcpm4WoAAlBcB.jpg News - Implementation of a basement membrane invasion assay using mesenteric tissue - Methods in Cell Biology http://biomechanicalregulation-lab.org/news/2019/10/1/chemically-functionalised-graphene-fet-biosensor-for-the-label-free-sensing-of-exosomes-scientific-reports monthly 0.5 2019-12-09 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1569941388649-A8DNO7W4YI8MI8REF3UF/News+2.png News - Chemically Functionalised Graphene FET Biosensor for the Label-free Sensing of Exosomes - Scientific Reports http://biomechanicalregulation-lab.org/news/2019/10/1/the-mutational-landscape-of-pancreatic-and-liver-cancers-as-represented-by-circulating-tumor-dna-frontiers-in-oncology monthly 0.5 2019-10-01 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1569941014229-O48H8ONWINVF3D3HUXO7/News+1.jpg News - The Mutational Landscape of Pancreatic and Liver Cancers, as Represented by Circulating Tumor DNA - Frontiers in Oncology http://biomechanicalregulation-lab.org/news/2019/5/22/matrix-stiffness-modulates-the-activity-of-mmp-9-and-timp-1-in-hepatic-stellate-cells-to-perpetuate-fibrosis-scientific-reports monthly 0.5 2019-05-22 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1558526420128-9AXMR0D28L68FNTSMXJF/41598_2019_43759_Fig6_HTML.png News - Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis - Scientific Reports http://biomechanicalregulation-lab.org/news/2019/5/2/engineering-the-cellular-mechanical-microenvironment-from-bulk-mechanics-to-the-nanoscale-journal-of-cell-science monthly 0.5 2019-05-02 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1556807245771-MQ66074NIQ2R9LD6XA77/inline-graphic-1.gif News - Engineering the cellular mechanical microenvironment: from bulk mechanics to the nanoscale - Journal of Cell Science http://biomechanicalregulation-lab.org/news/2019/1/14/repurposed-tamoxifen-alters-the-tumour-microenvironment-embo-reports monthly 0.5 2019-01-17 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1547473321458-R6TLKML70H0S7PAWPJRQ/EMBOR_Cover_vol20_01_RGB_ADRH.jpg News - Repurposed tamoxifen alters the tumour microenvironment — EMBO reports http://biomechanicalregulation-lab.org/news/2019/1/14/tamoxifen-mechanically-deactivates-hscs-through-gper-oncogene monthly 0.5 2019-01-17 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1547472701849-50G3VCY0F8U05UT0QBUC/41388_2018_631_Fig7_HTML.png News - Tamoxifen Mechanically Deactivates HSCs through GPER — Oncogene http://biomechanicalregulation-lab.org/news/2018/12/17/editors-peaks-cell-biology monthly 0.5 2019-01-17 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1545104664268-M0KFP3UK0S5UZV4LGI5J/talin.jpg News - Editor's peaks: Cell Biology http://biomechanicalregulation-lab.org/news/2018/12/17/tamoxifen-calms-down-the-distressed-pdac-stroma monthly 0.5 2018-12-18 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1545103801702-6HSZZ8LV0Q9HSLRBI9PN/figure%2Boskarsoon.jpg News - Tamoxifen calms down the distressed PDAC stroma http://biomechanicalregulation-lab.org/news/2018/12/17/article-tamoxifen-mechanically-reprograms-the-tumor-microenvironment-via-hif1a-and-reduces-cancer-cell-survival monthly 0.5 2018-12-18 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1545104965296-PUSTQ2F1GKLQOBLC5XZI/schematic%2Bsummary%2B3.jpg News - ARTICLE: Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival http://biomechanicalregulation-lab.org/news/2018/12/12/featured-work-on-the-imperial-college-website monthly 0.5 2018-12-13 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1544627470682-5YNWZ9WYDRXFQ0959JLV/website.png News - Featured work on the Imperial College website http://biomechanicalregulation-lab.org/news/2018/12/13/article-gper-is-a-mechanoregulator-of-pancreatic-stellate-cells-and-the-tumor-microenvironment monthly 0.5 2018-12-18 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1544716077679-IBKXL3QA3527YIG1O61M/figure+for+paper+1+website.jpg News - Article: GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment http://biomechanicalregulation-lab.org/news/2018/12/12/featured-work-on-the-imperial-college-website-1 monthly 0.5 2018-12-13 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1544634211541-DNGDTTGXFZBESVTHHDRM/from+Kemi.jpg News - Featured Work on the Imperial College Website http://biomechanicalregulation-lab.org/news/2018/7/31/article-rar-b-is-downregulated-in-hcc-cirrhosis-and-its-expression-inhibits-myosin-driven-activation-and-durotaxis-in-hepatic-stellate-cells monthly 0.5 2018-07-31 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1533067872038-KI4RPZ76BRPY2Q14XXUL/graph.jpg News - ARTICLE: RAR-B is downregulated in HCC & cirrhosis and its expression inhibits myosin-driven activation and durotaxis in hepatic stellate cells http://biomechanicalregulation-lab.org/news/2018/7/23/article monthly 0.5 2018-07-31 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1532366833270-UVRSEUBQ9ZT8VQP0JJZZ/Thumbnail+for+the+website.jpg News - ARTICLE: Mechanotransduction in talin through the interaction of the R8 domain with DLC1 http://biomechanicalregulation-lab.org/news/2018/5/10/phd-and-mres-graduations monthly 0.5 2018-05-10 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1525966378242-L6MGC37LXHTEYX9QBR44/Graduation+Photos.png News - PhD and Mres Graduations http://biomechanicalregulation-lab.org/news/2017/9/1/congratulations-to-antonios-on-passing-his-viva-way-to-go-dr-chronopoulos monthly 0.5 2017-09-01 http://biomechanicalregulation-lab.org/news/2017/6/5/article-matrix-stiffness-induces-epithelial-mesenchymal-transition-and-promotes-chemoresistance-in-pancreatic-stellate-cells monthly 0.5 2017-06-26 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496674257384-TQN748SPSZ0RE0NN6VP4/image-asset.jpeg News - ARTICLE: Matrix stiffness induces Epithelial-Mesenchymal transition and promotes chemoresistance in pancreatic cancer cells http://biomechanicalregulation-lab.org/news/2017/6/5/article-substrate-rigidity-controls-activation-and-durotaxis-in-pancreatic-stellate-cells monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496674109731-ER40HKPOD0ELST2GK7DO/image-asset.jpeg News - ARTICLE: Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells http://biomechanicalregulation-lab.org/news/2017/6/5/article-cross-linking-of-a-biopolymer-peptide-co-assembly-system monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496673849238-8SM9T8OMRJYDIMS3A92Q/image-asset.jpeg News - ARTICLE: Cross-linking of a biopolymer-peptide co-assembly system http://biomechanicalregulation-lab.org/news/2017/6/5/antonios-represents-cmbl-at-stem-for-britain monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496673599940-Z3MBSB6J73PFB891SRK1/image-asset.jpeg News - Antonios represents CMBL at STEM for Britain http://biomechanicalregulation-lab.org/news/2017/6/5/gordon-research-conference-texas monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496673404701-52OXUWNTVXJBDUOV7S73/image-asset.jpeg News - Gordon Research Conference, Texas http://biomechanicalregulation-lab.org/news/2017/6/5/cmbl-represent-at-eit-health-summit monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496672887395-UJA4IG9VDSRL1NWIZ4OF/image-asset.jpeg News - CMBL represent at EIT Health summit http://biomechanicalregulation-lab.org/news/2016/9/30/article-adhesive-ligand-tether-length-affects-the-size-and-length-of-focal-adhesions-and-influences-cell-spreading-and-attachment monthly 0.5 2016-11-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1475577961147-8K1H5CKKPDVMXRYFOR8D/image-asset.png News - ARTICLE: Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment http://biomechanicalregulation-lab.org/news/2017/6/5/antonios-wins-eit-gold-fellowship monthly 0.5 2017-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1496672733723-YZUXAZCWO7KHD636K6MJ/image-asset.jpeg News - Antonios wins EIT Gold Fellowship http://biomechanicalregulation-lab.org/news/2016/9/7/our-research-on-cancer-biophysics-uncovers-the-biomechanical-mechanism-by-which-vitamin-a-inhibits-the-invasion-of-pancreatic-cancer-cells monthly 0.5 2016-11-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1473250572063-4CMRFYMRQFYB85W2VZ2N/image-asset.png News - ARTICLE: Our research on cancer biophysics uncovers the biomechanical mechanism by which vitamin A inhibits the invasion of pancreatic cancer cells http://biomechanicalregulation-lab.org/news/2016/9/7/precision-medicines-conference-2016-strong-showing-from-cmbl monthly 0.5 2016-09-07 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1473248833995-SVFFHDXMF7Q4F7EIZUBB/image-asset.jpeg News - Precision Medicines Conference, 2016: strong showing from CMBL http://biomechanicalregulation-lab.org/news/2016/7/13/article-atra-modulates-mechanical-activation-of-tgf-by-pancreatic-stellate-cells monthly 0.5 2016-11-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1468402102409-RSUTRD512HWH5LX0FX4Y/image-asset.png News - ARTICLE: ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells http://biomechanicalregulation-lab.org/news/2016/7/13/article-all-subdomains-of-the-talin-rod-are-mechanically-vulnerable-and-may-contribute-to-cellular-mechanosensing monthly 0.5 2016-07-13 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1468401700013-GOBUJDKEKKNLG8NBX81I/image-asset.png News - Article: All Subdomains of the Talin Rod Are Mechanically Vulnerable and May Contribute To Cellular Mechanosensing http://biomechanicalregulation-lab.org/news/13052016 monthly 0.5 2016-07-13 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1463414281856-65YJBMTI52S75M4TEGS8/image-asset.png News - Article: Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells http://biomechanicalregulation-lab.org/news/2016/3/31/paper-published monthly 0.5 2016-05-16 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1463414689182-P6LBKLWO72EDIFV096UK/image-asset.png News - International Liver Congress 2016 http://biomechanicalregulation-lab.org/news/2016/3/31/tylerwhitaker monthly 0.5 2016-05-16 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1463414885384-RIZJQXWTMYMSKDJW67U8/image-asset.png News - Whitaker International Program Enrichment Seminar 2016 http://biomechanicalregulation-lab.org/news/2016/4/20/exosonic-wins-audience-choice-award monthly 0.5 2016-05-16 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1463418750925-MJCO0709MCEYHCFPVG8T/image-asset.jpeg News - ExoSonic wins Audience Choice Award http://biomechanicalregulation-lab.org/people-3 daily 0.75 2016-11-14 http://biomechanicalregulation-lab.org/new-gallery-2 daily 0.75 2016-11-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1479213863915-KEE0SDYHCQ70CBF61EH6/Picture1.png Awards CMBL receives ICIC award to develop microfluidic technology for integrated isolation and analysis of tumour exosomes https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1479213896445-Q7DW29KTXCYHQCSV90U7/Picture2.jpg Awards Antonis Chronopoulos receives PhD – postdoctoral transitional fellowship from the European Institute of Innovation and Technology http://biomechanicalregulation-lab.org/cover daily 0.75 2017-06-05 http://biomechanicalregulation-lab.org/publications daily 0.75 2023-02-13 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1570451096033-W4XSE3A99QPO0A65DSDH/Cover+1_2.png Publications https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1578596803596-OOSOX728CUXYLYBX5ULH/cover_Syndecan_sketch_v2_A4_300ppp.png Publications https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1570451122414-ZC28K0050ZW4IREJJ0WN/Cover+4.jpg Publications https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1570466229930-2QJS7Z30ND5L233675PJ/Cover+2_2.jpg Publications http://biomechanicalregulation-lab.org/useful-links daily 0.75 2014-11-10 http://biomechanicalregulation-lab.org/mech-response daily 0.75 2015-04-23 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429785811922-DOMNKPF75JS2TTTAVX7M/image-asset.png Mech Response http://biomechanicalregulation-lab.org/elastic-pillars daily 0.75 2016-01-18 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401373880433-F77R3ABHFTMHKQ57QYTJ/1.png Elastic Pillars https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401718147952-P6JSM77843O5T1VTX9MH/image-asset.png Elastic Pillars   Eq.1. The relation between deflection, Δx and force where the spring constant k is determined by pillar properties E, Young’s modulus, D Pillar diameter and L, pillar length. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401270576007-40Q34TNI7H9UO8ZWTRBN/image-asset.gif Elastic Pillars Pillars used for Time vs. Deflection plots and the analysis of peak forces applied by the stellate cells during spreading. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429717958005-BNGZWI3JB1U9JEKQNR6H/image-asset.png Elastic Pillars We use custom algorithms to quantify the forces that cells exert on pillars. (A) Microscopic image of a pillar array with a cell placed on the pillars. (B) Vector-map that represents the magnitude and direction of the force applied by the cell on each pillar. (C) Heat map for the force generated by this cell on the pillars https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401383058646-GNL72TLIAZ0RUH8A97SX/2.jpg Elastic Pillars Time vs. Pillar deflection traces of cells on 6 micron pillars. Each trace shows the calculated peak force value. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401270407761-2ALFIAGKVMY05OKZ5XLL/image-asset.gif Elastic Pillars Cell spreading on 6 micron pillars with image acquisition at 2 second intervals for 15 minutes (video 100X faster). https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429784926217-THYA1QB15RYN280B0MB1/image-asset.png Elastic Pillars Immunofluorescence images of cells on 1um pillars. The images show the location of paxillin (green) and myosin (red). https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1453131307905-B95QC9DZ9O0ZK7YROHZ2/pillarsspreadsmaller.gif Elastic Pillars Deflection of pillars during cell spreading https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1453131537102-D585G1ZNRQJA68AE9R7V/cellcontraction.gif Elastic Pillars Deflection of pillars during cell contraction http://biomechanicalregulation-lab.org/confocal-microscopy daily 0.75 2014-06-05 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401962318779-3P5EM9KQVZK8RT45XY5J/diag.jpg Microscopy Schematic representation of the microscope system depicting the light path of illumination sources (Brightfield and fluorescence lamp, Laser) to the sample and the emission path (green). https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401270905509-TV2YL4ZD6PU2RXMBWSZ5/image-asset.jpeg Microscopy The Nikon Eclipse Ti inverted microscope with additional imaging detectors (sCMOS and confocal) contained with an incubation chamber for cellular imaging. http://biomechanicalregulation-lab.org/techoverview daily 0.75 2016-11-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401803711692-5GWI7BRJGJDZQW2R8AP9/confmicr Overview CONFOCAL MICROSCOPY https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401806588826-NIPAOE9WUHKH2RFVM0CU/image-asset.png Overview ELASTIC PILLARS https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401800867110-YRNUVKAQ62FYWVEK5DCD/tissue Overview PROTEIN EXPRESSION AND PURIFICATION https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401800896300-H0AP5QN9J8NXJB38XE5H/image2993.png Overview TISSUE CULTURE https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1479210911893-D08547DLCKRU9O5C5315/afm-r.png Overview ATOMIC FORCE MICROSCOPY https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401801019688-JUPS4A6W2S0MDQQE9IQ6/006.JPG Overview SINGLE-MOLECULE ATOMIC FORCE MICROSCOPY https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401801642201-MAAJVK3L53FP5FJ8DPXM/1b.jpg Overview MAGNETIC TWEEZERS https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1453109541304-2YU9X19CQXR78SHOAW3Y/MICROFLUIDICS Overview MICROFLUIDICS http://biomechanicalregulation-lab.org/afm daily 0.75 2014-06-04 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401720363140-JX1D3JKQ15UKQWWGNOAX/image-asset.png AFM https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401718806324-WLV1OI2RUX5TLYN6I2HO/CellElasticityBasics2.png AFM https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401719460641-53GMLQRWBJT19IIC0PPR/4.png AFM SEM images of AFM cantilever with and without a 15um bead with optical images of a bead attached and approaching fibroblast cells. SEM images from [Harris et al 2011]. http://biomechanicalregulation-lab.org/tissue-culture daily 0.75 2014-11-03 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401874162025-18T7P69CI4EZ5NNHNSZR/image-asset.png Tissue Culture http://biomechanicalregulation-lab.org/smfs daily 0.75 2016-08-09 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401812305432-NKKPAVU7KP1HWTICZPDS/image-asset.gif SMFS https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401812429424-T5S9VL3XH6JE1R139XE6/g7159.png SMFS https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1453124359715-SZWRL3H6O5W3JIHUUAAE/image-asset.gif SMFS Animation of AFS unfolding of a talin-Ig construct http://biomechanicalregulation-lab.org/molecular-biology daily 0.75 2026-03-11 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/b915e9f6-db67-4a2c-8aa6-f64f2c0ef7f1/figura.jpg Molecular Biology Lab https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401961605454-VIGTAAW2BIORS0X24EZB/image-asset.png Molecular Biology Lab https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401970892378-W9UXIEXXUSUKF1IL8TG6/image-asset.png Molecular Biology Lab http://biomechanicalregulation-lab.org/pancreatic-cancer daily 0.75 2015-04-23 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429792729653-KU1IG9F1O11ORXG3DVMX/image-asset.png Pancreatic Cancer Clockwise from top right: location of pancreas; enhanced brightfield image of pancreatic stellate cells; two-photon second harmonic image of a normal pancreatic tissue showing collagen distribution around the pancreatic ducts. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429791993049-7Z3Y95OM4LFQ206XNKPI/image-asset.jpeg Pancreatic Cancer http://biomechanicalregulation-lab.org/cellular-mechanotransduction daily 0.75 2014-09-27 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401278891238-PHLKSDBQHJDZRQS4PJ65/image-asset.png Cellular Mechanotransduction https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401295588252-6S5KZ38QYUBAHUXH7HVY/image-asset.png Cellular Mechanotransduction http://biomechanicalregulation-lab.org/breast-cancer daily 0.75 2014-12-15 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401290881402-35CT8XW68XFC3IOWNHCF/image-asset.png Breast Cancer Schematic representation of transition from normal human breast to DCIS and invasive cancer. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401290329217-IQ8CCJ5OTCZYC8YBYT87/image-asset.png Breast Cancer Schematic representation of the structure of normal human breast. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401290487371-FV0MX37E9NF2Y9ZQ0JBA/image-asset.png Breast Cancer DIC image of a human breast fibroblast. http://biomechanicalregulation-lab.org/overview daily 0.75 2016-04-29 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401898430603-RDXUPWW0BIPY5D8W82PR/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401898448142-3VH8U9UJLWV8CWZ48ZQG/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401898479918-BJY9JW23FBDD0SR8A3U6/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1461943872068-IDTR0V5737AS1CURMIAY/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1435926892114-TZZUSHXQWDV3HFTNSKU5/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1435926682453-8231CGCV01LFV1D0STPQ/image-asset.png Overview https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1454151902367-RDTWBA7D42FERYDQEGEQ/JDF+logo.png Overview 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Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1416841528237-6T419H3ZP7EXQAL4ORDY/image-asset.png Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1426683847752-54IUZ1NM5VL8TLICB8XU/image-asset.jpeg Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1441369387001-BB6XWTDL3L1UEZ9ISENX/image-asset.jpeg Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1440022893746-191G8FL4U8DSFX1IUISI/image-asset.png Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1481815187054-TERVWMPSRVMP9Q7LG6KP/DSC02191.jpg Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1447085514134-Q7J2N7EXKJAHAFCA9S2S/mark+wilkinson.png Current Members https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1476461800490-R1NLQ5TPELXGMS3T9INQ/image-asset.jpeg Current Members 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https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429785392120-720P4BLHZA2QD0ESBMJP/image-asset.gif Microrheology https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429785359429-Z072KSLMAG63XIECDSGD/image-asset.png Microrheology   J0= Cell Compliance (inverse of stiffness) β = Fluidity (dimensionless quantity) http://biomechanicalregulation-lab.org/magnetic-tweezers-1 daily 0.75 2021-02-10 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401723564830-S72Q3L3MZM7EP85EEBY3/image-asset.png Magnetic Tweezers https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429803434698-YASWEN13W8R9YQMCJZ0C/image-asset.gif Magnetic Tweezers CALIBRATION OF MAGNETIC TWEEZERS - For laminar flows, a spherical bead, in response to an applied force F, will move with a velocity v = F/ 6πηr, where η is the dynamic fluid viscosity and r is the radius of the bead. Consequently, the force applied to a magnetic bead can be calculated by tracking the displacement of the bead over a period of time. Shown above: (top) the beads embedded in a media of known viscosity, (bottom left) the tracking of the position of the spherical magnetic bead, and (bottom right) the force calibration curves. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429701177635-6C8WVR06V7PNWAWWFFCP/Picture1.png Magnetic Tweezers https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429701273851-Q48BMJ82VKFDSALIP421/image-asset.png Magnetic Tweezers https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429701370789-MJ6ELRBH8MUK3A0DZ4PS/Picture3.png Magnetic Tweezers https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429701391882-89QD4K21T8HPCG6DZ80C/image-asset.png Magnetic Tweezers https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429781977487-0787UJVMHH8OKOBZH54O/image-asset.gif Magnetic Tweezers This graphic shows this technique being used to investigate the microrheology of a cell. A single bead is tracked as a force pulse is applied to it; visco-elastic models can be fit to the resulting displacement of the bead and properties such as viscosity and elasticity can be obtained. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1453980180673-1636YDOGJZYZBHRCVYWR/tweezerscoil.gif Magnetic Tweezers Magnetic tweezers are used to apply localised tensional force on mechanosensitive cell adhesion receptors. The applied tension causes an adaptive remodelling of the cytoskeleton and strengthening of the adhesion complex as seen by the progressive reduction in the bead movement. https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1401188190437-2NB7B57HJP5BEEQ40NCN/5.png Magnetic Tweezers Guilluy et al. 2014 http://biomechanicalregulation-lab.org/adhesion-strength daily 0.75 2015-04-23 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429786491468-IG63XHVNSOGH85I9GB0B/detachment2.gif Adhesion Strength https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1429785974011-969883WLS3HTAXD21LP4/image-asset.png Adhesion Strength http://biomechanicalregulation-lab.org/photolithography daily 0.75 2016-04-29 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1452880577059-8NZZJ7XNIUFF2U5YN4AU/image-asset.png Photolithography The process of photolithography to make a microfluidic device https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1461942599997-H843EINYW73OKWHN8SF3/image-asset.png Photolithography Gold patterned CMBL logo created using photolithography, gold evaporation and lift-off http://biomechanicalregulation-lab.org/microfluidics daily 0.75 2016-04-29 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1461943043227-DQWFC657M802VOTPCXHQ/image-asset.jpeg Microfluidics The separation of biomarkers using microfluidics https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1461941207985-E7TYE1DGW6VKAUS4C85F/image-asset.png Microfluidics Fluid profile regimes in microfluidics https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1461941224213-M7SW7BMU0ZASBRILAHNE/image-asset.png Microfluidics A microfluidic device on a fluorescent microscope http://biomechanicalregulation-lab.org/past-members daily 0.75 2016-10-25 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https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466599642830-87NTGZM4LE8EYDRKESBU/image-asset.jpeg Imperial Festival https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600412449-6EP2HF0K5SWOAOPUQ29A/image-asset.jpeg Imperial Festival Darek demonstrates how sound can generate force with cornflour https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600453354-MQ09CZHYIT2TUQSHZG0Y/image-asset.jpeg Imperial Festival Standing wave generation occurs as part of our device, and this spring and speaker demonstrated what a standing wave is https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600489831-LHNOJOZRWAHFMCSSW7UF/image-asset.jpeg Imperial Festival Alistair creates a standing wave with a Slinky https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600756454-ZBDH0B9QIWNAE0ETX86U/image-asset.jpeg Imperial Festival Antonis explains the principles of our device https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600802542-5E3K2VP7IWNL6CB02NTL/image-asset.jpeg Imperial Festival Darek answers questions from visitors https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466600669510-GS85JU759VW00OJFUV1D/image-asset.jpeg Imperial Festival Ben talks about exosomes https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466606140593-NJEZ3MKCCBLUW8SEZHJF/image-asset.jpeg Imperial Festival Feedback was very positive! https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1466606103733-DZNM0233E4424PN0DGDW/image-asset.jpeg Imperial Festival The CMBL team at Imperial Festival http://biomechanicalregulation-lab.org/y10-insights daily 0.75 2016-11-29 https://images.squarespace-cdn.com/content/v1/51acda21e4b0be9ceadc57b3/1469721256914-UA9V601QZ8JINQVDP6RD/image-asset.jpeg Y10 Insights Antonis shows the magnetic tweezers to Year 10 students 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