repurposing tamoxifen - a new mechanism of action opens novel therapeutic possibilities

Using vitamin A to target early and late liver diseases via mechanotransduction. To see the video click here.

To read the paper click here.

“Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.” Oncogene (2018)

Cortes E, Lachowski D, Rice A, Thorpe S, Robinson B, Yeldag G, Lee D, Ghemtio L, Rombouts K, del Río Hernández A.