Selected publications
Lachowski D, Matellan C, Gopal S, Cortes E, Robinson B, Saiani A, Miller A, Stevens M, and del Río Hernández A. Substrate Stiffness-Driven Membrane Tension Modulates Vesicular Trafficking via Caveolin-1. ACS Nano 2022.
Mehta V, Pang KL, Rozbesky D, Nather K, Keen A, Lachowski D, Kong Y, Karia D, Ameismeier M, Hung J, Fang Y, del Río Hernández A, Reader JS, Jones Y, Tzima E. The guidance receptor plexin D1 is a mechanosensor in endothelial cells. Nature 2020.
Chronopoulos A, Thorpe SD, Cortes E, Lachowski D, Rice AJ, Mykuliak V, Róg T, Lee DA, Hytönen VP & del Río Hernández A. Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. Nature Materials 2020. To see the summary video click here.
Guilluy C and Dolega ME. Syndecan-4 forces integrins to cooperate. Nature Materials 2020.
Cortes E, Lachowski D, Robinson B, Sarper M, Teppo J, Thorpe S, Lieberthal T, Iwamoto K, Lee D, Okada‐Hatakeyama M, Varjosalo M, del Río Hernández A. Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival. EMBO Reports 2019.
Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe S, Lee D, del Río Hernández A. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports 2019.
Dooling LJ and Discher DE. Inhibiting tumor fibrosis and actomyosin through GPCR activation. Trends in Cancer 2019.
The cover of the January 2019 issue highlights our back to back EMBO reports manuscripts (above). Click here
Pein M and Oskarsson T. Tamoxifen calms down the distressed PDAC stroma. News and Views about our back to back EMBO reports manuscripts. Read it here
Cortes E, Lachowski D, Rice A, Thorpe S, Robinson B, Yeldag G, Lee D, Ghemtio L, Rombouts K, del Río Hernández A. Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene 2018. To see the summary video click here
Cortes E, Lachowski D, Rice A, Robinson B, Thorpe S, Lee DA, Possamai LA, Wang H, Pinato D, and del Río Hernández A. RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology 2018. To see the summary video click here
Blaner WS. Hepatic stellate cells and retinoids: Toward a much more defined relationship. Editorial about our Hepatology manuscript above. Read it here
Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice AJ, von Essen M, Hytönen VP, del Río Hernández A. Mechanotransduction in talin through the interaction of the R8 domain with DLC1. PLoS Biology 2018. To see the summary video click here.
Included in the Editor’s picks collection: Cell Biology
Elshawarky S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina NV, Wilson RM, Bushby AJ, Alonso M, Rodriguez-Cabello JC, Barbieri E, del Río Hernández A, Stevens MM, Pugno NM, Anderson P, Mata A. Protein disorder–order interplay to guide the growth of hierarchical mineralized structures. Nature Communications 2018
Leads the Top 50 in Chemistry and Materials Science collection
Von Erlach, TC, Bertanzzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson B, Autefage H, Kallepitis C, del Río Hernández A, Chen CS, Goldoni S, Stevens MM. Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. Nature Materials 2018
Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B & del Río Hernández A. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nature Communications 2016
Haining AWM, von Essen M, Attwood SJ, Hytonen VP, del Río Hernández A. All subdomains of the talin rod are mechanically vulnerable and may contribute to cellular mechanosensing ACS Nano 2016
