MRes Projects:

Please click the titles for more information.

Biomechanical characterization of human breast cancer cells & constraint migration

Biomechanics of breast cancer

Biomechanics of Hepatic Stellate Cells

Biomechanics of pancreatic cancer

Development of 3D scaffold for the analysis of tumour growth-induced stress

Elucidating the role of ROCK in the biomechanics of pancreatic tumour cells

Liquid biopsy for early detection of pancreatic cancer

Mechanical activation of deleted in liver cancer (DLC1) molecule in cancer cells

Modelling the dynamic complex of EMT in pancreatic cancer

PDAC pre-metastatic niche in liver

Protein unfolding a mechanical switch to control cell behaviour

Testing pancreatic cancer cell invasion using mesenteries

The effect of solid stresses in tumour growth

Example of previous report using mesenteries to mimic BM

Examples of previous peer-reviewed articles involving MRes students:

Enanga E - MRes in Cancer Bioinformatic - 2017/2018

  • Vella A, Enanga E. and del Rio Hernandez A. The emergence of solid stress as a potent biomechanical marker of tumor progression. Submitted

Ghose R - MRes in Cancer Research - 2017/2018

  • Ghose R, Ghose U, Cortes E, Rice A, LAchowski D, and del Rio Hernandez A. Q-Pi: A Novel tool for the quantification of invasion. Submitted

Julia MG - MRes in Biomedical Research - 2017/2018

  • Samandari M, Julia MG, Rice A, Chronopoulos A, and del Rio Hernandez A. Liquid Biopsies for management of pancreatic cancer. 2018 Translational Reseach 2018

Walker C, Mojares E - MRes in Bioengineering 2017/2018

Matellan C - MRes in Bioengineering 2016/2017

  • Matellan C, del Rio Hernandez A.  Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices. Scientific Reports 2018

Cheung CH - MRes in Bioengineering 2016/2017

  • Rice AJ, Cortes E, Lachowski D, Cheung CH, Karim SA, Morton JP, del Río Hernández A. Matrix stiffness induces Epithelial-Mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis 2017

Pink D (co-first author) - MRes in Bioengineering 2015/2016

  • Lachowski D, Cortes E, Pink D, Chronopoulos A, Karim SA, Morton JP,  del Río Hernández A. Substrate rigidity controls activation and durotaxis in pancreatic stellate cells. Scientific Reports 2017

Garcia R - MRes in Biomedical Research 2014-2015

  • Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B & del Río Hernández A. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion.  Nature Comms 2016