Syndecan 4 Model

Syndecan-4: A Key Player in Global Cellular Mechanotransduction Events

CMBL reveals a mechanism whereby syndecan-4 tunes cell mechanics in response to localized tension via a coordinated mechanochemical signalling

To see the video click here.

To read the paper click here.

“Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway.” Nature Materials (2020)

Antonios Chronopoulos, Stephen D. Thorpe, Ernesto Cortes, Dariusz Lachowski, Alistair J. Rice, Vasyl V. Mykuliak, Tomasz Róg, David A. Lee, Vesa P. Hytönen & Armando E. del Río Hernández