Cortes E, Lachowski D, Robinson B, Sarper M, Teppo J, Thorpe S, Lieberthal T, Iwamoto K, Lee D, Okada‐Hatakeyama M, Varjosalo M, del Río Hernández A. Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival. EMBO Reports 2019.

Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe S, Lee D, del Río Hernández A. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Reports 2019.

Dooling and Discher DE Inhibiting tumor fibrosis and actomyosin through GPCR activation. Trends in Cancer 2019.

The cover of the January 2019 issue highlights our back to back EMBO reports manuscripts (above). Click here

Pein and Oskarsson. Tamoxifen calms down the distressed PDAC stroma. News and Views about our back to back EMBO reports manuscripts. Read it here

Lachowski D, Cortes E, Rice A, Pinato D, Rombouts K, and del Río Hernández A. Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis. Scientific Reports 2019

Matellan C, del Rio Hernandez A. Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale. Journal of Cell Science 2019

Matellan C, del Rio Hernandez A.  Where No Hand Has Gone Before: Probing Mechanobiology at the Cellular Level. ACS Biomaterials Science and Engineering 2019

Rice A, del Rio Hernandez A. The Mutational Landscape of Pancreatic and Liver Cancers, as Represented by Circulating Tumor DNA. Frontiers in Oncology 2019

Kwong Hong Tsang D, Lieberthal T, Watts C, Dunlop IE, Ranadan S, del Rio Hernandez A, and Klein N.  Chemically Functionalised Graphene FET Biosensor for the Label-free Sensing of Exosomes. Scientific Reports 2019.

Perone Y, Farrugia AJ, Meira AR, Győrffy B, Ion C, Uggetti A, Chronopoulos A, Marrazzo P, Faronato M, Shousha S, Davies C, Steel JH, Patel N, Del Rio Hernandez A, Coombes C, Pruneri G, Lim A, Calvo F, Magnani L. SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer. Nature Communications 2019


Cortes E, Lachowski D, Rice A, Thorpe S, Robinson B, Yeldag G, Lee D, Ghemtio L, Rombouts K, del Río Hernández A. Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor. Oncogene 2018. To see a video click here

Cortes E, Lachowski D, Rice A, Robinson B, Thorpe S, Lee DA, Possamai LA, Wang H, Pinato D, and del Río Hernández A. RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells. Hepatology 2018.  To see a video click here

Blaner WS. Hepatic stellate cells and retinoids: Toward a much more defined relationship. Editorial about our Hepatology manuscript above. Read it here

Haining AWM, Rahikainen R, Cortes E, Lachowski D, Rice AJ, von Essen M, Hytönen VP, del Río Hernández A. Mechanotransduction in talin through the interaction of the R8 domain with DLC1. PLoS Biology 2018. To see a video click here.

Included in the Editor’s picks collection: Cell Biology

Elshawarky S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina NV, Wilson RM, Bushby AJ, Alonso M, Rodriguez-Cabello JC, Barbieri E, del Río Hernández A, Stevens MM, Pugno NM, Anderson P, Mata A. Protein disorder–order interplay to guide the growth of hierarchical mineralized structures. Nature Communications 2018

Leads the Top 50 in Chemistry and Materials Science collection

Yeldag G, Rice A, del Rio Hernandez A. Chemoresistance and the self-maintaining microenvironment. Cancers 2018.

Cover of December 2018 issue

Vella A, Enanga E, Rio Hernandez A. The emergence of solid stress as a potent biomechanical marker of tumour progression. Emerging Topics in Life Sciences 2018

Matellan C, del Rio Hernandez A.  Cost-effective rapid prototyping and assembly of poly(methyl methacrylate) microfluidic devices. Scientific Reports 2018

Mykuliak VV, Haining AWM, von Essen M, del Río Hernández A, Hytönen VP. Mechanical unfolding reveals stable 3-helix intermediates in talin and α-catenin. PLoS Computational Biology 2018

Samandari M, Julia MG, Rice A, Chronopoulos A, del Río Hernández A. Liquid biopsies for management of pancreatic cancer. Translational Research 2018

Walker C, Mojares E, del Río Hernández A. Role of extracellular matrix in development and cancer progression. International Journal of Molecular Sciences 2018

Von Erlach, TC, Bertanzzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson B, Autefage H, Kallepitis C, del Río Hernández A, Chen CS, Goldoni S, Stevens MM. Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. Nature Materials 2018


Lachowski D, Cortes E, Robinson B, Rice AJ, Rombouts K, del Río Hernández A. FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.  FASEB J 2017

Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall A, Kong K, Frenguelli L, Marrone G, Willacy O, Shaeri M, Burns A, Malago M, Gilbertson J, Rendell N, Moore K, Hughes D, Notingher I, Jell G, del Río Hernández A, De Coppi P, Rombouts K, Pinzani M. Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization. Scientific Reports 2017

Rice AJ, Cortes E, Lachowski D, Cheung CH, Karim SA, Morton JP, del Río Hernández A. Matrix stiffness induces Epithelial-Mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis 2017

Mohri Z, del Río Hernández A, Krams R. The emerging role of YAP/TAZ in mechanotransduction. Journal of Thoracic Disease 2017

Lachowski D, Cortes E, Pink D, Chronopoulos A, Karim SA, Morton JP,  del Río Hernández A. Substrate rigidity controls activation and durotaxis in pancreatic stellate cells. Scientific Reports 2017

Inostroza-Brito KE, Collin EC, Poliniewicz A, Elsharkawy S, Rice AJ, del Río Hernández A, Rodriguez-Cabello J, Mata A. Cross-linking of a biopolymer-peptide co-assembly system. Acta Biomaterialia 2017

Chronopoulos A, Lieberthal TJ, del Río Hernández A. Pancreatic cancer: a mechanobiology approach. Convergent Science Physical Oncology 2017

Chronopoulos A, Lieberthal TJ, del Río Hernández A. Exosomes as a platform for 'liquid biopsy' in pancreatic cancer. Convergent Science Physical Oncology 2017


Attwood SJ, Cortes E, Haining AWM, Robinson B, Li D, Gautrot J, del Río Hernández A. Adhesive ligand tether length affects the size and length of focal adhesions and influences cell spreading and attachment. Scientific Reports 2016

Chronopoulos A, Robinson B, Sarper M, Cortes E, Auernheimer V, Lachowski D, Attwood S, García R, Ghassemi S, Fabry B & del Río Hernández A. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion.  Nature Communications 2016

Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, del Río Hernández A, Towhidi L, Pedrigi RM, Homma T, Krams. Development of a synthetic gene network to modulate gene expression by mechanical forces. Scientific Reports 2016

Haining AWM, von Essen M, Attwood SJ, Hytonen VP, del Río Hernández A. All subdomains of the talin rod are mechanically vulnerable and may contribute to cellular mechanosensing ACS Nano 2016

Sarper M,  Cortes E, Lieberthal TJ, del Río Hernández A. ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells. Scientific Reports 2016

Robinson BK, Cortes E, Rice AJ, Sarper M, del Río Hernández A. Quantitative analysis of 3D extracellular matrix remodelling by pancreatic stellate cells. Biology Open 2016

Haining AWM, Lieberthal TJ, del Río Hernández A. Talin: a mechanosensitive molecule in health and disease. FASEB J 2016.


Roca-Cusachs P, del Rio A, Pucklin-Faucher E, Gauthier NC, Biais, N and and Sheetz, M. Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation Proc Natl Acad Sci USA, 2013, Vol: 110, Pages: 1361-1370. Link

Roca-Cusachs P, Gauthier NC, del Rio A, and Sheetz, M. Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction, Proc Natl Acad Sci USA, 2009, Vol: 106, Pages: 16245-16250. Link

del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, and Sheetz, M. Stretching single talin rod molecules activates vinculin binding. Science, 2009, Vol: 323, Pages: 638-641. Link

del Rio A, Dutta K, Chavez J, Ubarretxena-Belandia, and Ghose, R. Solution structure and dynamics of the N-terminal cytosolic domain of rhomboid intramembrane protease from Pseudomonas aeruginosa: Insights into a functional role in intramembrane proteolysis, Journal of Molecular Biology 2007, Vol:365, Pages:109-122. link

del Rio A, Anand A, Ghose R. Detection of correlated dynamics on multiple timescales by measurement of the differential relaxation of zero- and double-quantum coherences involving sidechain methyl groups in proteinsJournal of Magnetic Resonance 2006, Vol:180, Pages:1-17. link

del Rio A, Coto B, Pando C, and Renuncio, JAR. Vapor-liquid equilibria for the binary system 2,2-dimethylbutane plus 1,1-dimethylpropyl methyl ether (TAME) at 298.15, 318.15, and 338.15 K, Fluid Phase Equilibria 2004, Vol: 221, Pages: 1-6. Link

Spuhl, O.; Artl, W.; and Hernandez, A. (2003) Prediction of thermodynamic material properties with the COSMO-RS continuum modelChem. Ing. Tech. Vol: 75 (1-2), Pages: 58-62. Link

de Llano JJ, Segade L, Jimenez E, Pando C, and Renuncio, JAR. Vapor-liquid equilibria for the binary system hexan-1-ol plus tert-butyl methyl ether (MTBE) at 298.15, 318.15, and 338.15 K. Fluid Phase Equilibria 2003, Vol: 208, Pages: 115-121. Link

Segade L, de Llano JJ, Jimenez, Pando C, and Renuncio, JAR. Vapor-liquid equilibria of propan-1-ol+1,1-dimethylethyl methyl ether (MTBE) mixtures. Experimental results and modeling. Physical Chemistry Chemical Physics, 2003, Vol: 5, Pages: 2858-2861. Link

del Rio A, Coto B, Pando C, and Renuncio JAR. Vapor-liquid equilibria and excess properties of octane+1,1-dimethylpropyl methyl ether (TAME) mixturesFluid Phase Equilibria 2002, Vol: 200, Pages: 41-51. Link

del Rio A, Coto B, Pando C, and Renuncio JAR. Vapor-liquid equilibria for the binary system hexane+1,1-dimethylpropyl methyl ether at 298.15, 308.15, 318.15, and 328.15 K. Industrial and Engineering Chemistry Research 2002, Vol: 41, Pages: 1364-1369. Link

del Rio A, Coto B, Pando C, and Renuncio JAR. Vapor-liquid equilibria for the binary systemsdecane+1, 1-dimethylethyl methyl ether (MTBE) and decane+1, 1-dimethylpropyl methyl ether (TAME) at 308.15, 318.15 and 328.15 K Fluid Phase Equilibria 2001, Vol: 187, Pages: 299-310. Link

del Rio A, Coto B, Pando C, and Renuncio JAR. Vapor-liquid equilibria and excess properties of cyclohexane-1,1-dimethylpropyl methyl ether (TAME) mixtures, Industrial & Engineering Chemistry Research 2001, Vol: 40, Pages: 689-695. Link

del Rio A, Horstmann S, Renuncio JAR, and Gmehling J. Isothermal Vapor-Liquid Equilibrium and Excess Enthalpy Data for the Binary Systems Methyl tert-Butyl Ether + Cyclohexane and Ethyl tert-Butyl Ether + Cyclohexane, n-Hexane, and n-Heptane in a Temperature Range from 298.15 to 393.15 K.Journal of Chemical Engineering Data, 2001, Vol: 46, Pages: 1181-1187. Link

del Rio A, Coto R, Pando C, and Renuncio JAR. Vapour-liquid equilibria for the binary system cyclohexane-1,1-dimethylethyl methyl ether (MTBE) at 298.15, 308.15 and 318.15 K, Physical Chemistry Chemical Physics, 1999, Vol: 1, Pages: 4995-4998. Link

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